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Abbreviations KIC: -Ketoisocaproate KIV: -Ketoisovalerate KMV: -Keto--methylvalerate AD: Alzheimers disease A: Amyloid APP: Amyloid precursor protein BCAA: Branched chain amino acids BCAT: Branched chain aminotransferase BCATc: Cytosolic BCAT BCATm: Mitochondrial BCAT BCKA: Branched chain -keto acids BCKD: Branched chain -keto acid dehydrogenase Cho: Choline Cr: Creatinine Glu: Glutamate Glx: Glu+glutamine GDH: Glutamate dehydrogenase MSUD: Maple syrup urine disease NAA: N -acetyl aspartate NMDAR: N -methyl-d-aspartate receptor NFTs: Neurofibrillary tangles PLP: Pyridoxal phosphate PSEN1: Presenilin 1 1 H MRS: Proton magnetic resonance spectroscopy mI: Myoinositol TBI: Traumatic brain injury References Albin RL, Greenamyre JT (1992) Alternative excitotoxic hypotheses